性狀: 為粘多糖的分解酶,可水解組織基質(zhì)中的主要成分透明質(zhì)酸,增加組織的通透性,從而促使皮下輸液和局部積貯的滲出液或血液的吸收。臨床可用于加速皮下、肌肉注射藥液的吸收,促進(jìn)局麻藥的浸潤(rùn),減輕注射部分疼痛,促進(jìn)手術(shù)及創(chuàng)傷后局部水腫或血腫的消散。Enzyme Commission (EC) Number: 4.2.2.1 透明質(zhì)酸酶是從牛睪丸中分離提取的,并進(jìn)一步用層析的方法制備,以去除殘留的其它蛋白酶的污染。 Unit Definition One unit will cause a change in A600 of 0.330 per minute at pH 5.7 at 37°C in a 2.0 ml reaction mixture (45 minute assay).
質(zhì)量標(biāo)準(zhǔn): Appearance A white or yellowis-white powder Identification Complies pH 4.5 – 7.5 Appearance of solution Clear Loss on drying ≤ 5.0% Bacterial endotoxins Less than 0.2 IU per IU of hyaluronidase Limit of tyrosine ≤ 0.25 μg per USP Hyaluronidase U. Activity ≥ 300 IU/mg powder